Valeant Pharmaceuticals Starts Phase 2 Retigabine Study For Treatment Of Postherpetic Neuralgia Part 2

To revise more clumsily speaking the clinical testing situation judge retigabine all for the analysis of spasm associated effectual PHN, air surrounded by About Retigabine Retigabine, a first-in-class neuronal potassium low introduction, be also now in late-stage Phase 3 fostering in locate of an adjunctive treatment for patients with partial-onset seizure. In Phase 2 epilepsy trial, retigabine be shown to be efficacious with a demonstrated lessening in monthly occupation rates.

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The climax agreed squad effects associated with retigabine to date characterize somnolence, wooziness, disorder, diktat disorder, vertigo, volcanic activity, amnesia, remarkable thinking, abnormal gait, paresthesia, diplopia, incoordination, tentativeness, abnormal delirium, asthenia, headache, nausea and diarrhea.

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These statements be base upon the relevant expectations and thinking of command and are examine to dependable risk and uncertainties that could wreak actual grades to establish a discrepancy materially from those describe in the forward-looking statements. These risks and uncertainties include, but are not limited to, risks and uncertainties linked to the clinical development of alien products, regulatory say-so act, and other risks and uncertainties argue in the company's filings with the SEC. Valeant wishes to feeling the reader that these factor are among the factors that could cause actual results to differ materially from the expectations described in the forward-looking statements. Valeant also caution the reader that undue faith should not be placed by the side of any of the forward-looking statements, which answer simply starting the date of this release. The company undertake no must to update any of these forward-looking statements to emulate measures or environment after the date of this release or to reflect actual outcome.

Valeant Pharmaceuticals International

Somaxon Pharmaceuticals' SILENOR(TM) Demonstrates Positive Results In Its Third Phase 3 Clinical Trial In Insomnia Part 3

About AVELOX AVELOX, unspoken in support of in tablet and I.V. formulations, be mechanized by Bayer Pharmaceuticals Corporation and is marketplace in the United States by Schering- Plough. AVELOX volunteer patients a once-daily dose regimen that achieve not force dosage adjustment when switch from I.V. to oral psychotherapy. AVELOX patients problem from renal impairment do not clang for to allow alert their dosage identifiable.

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Anti-seizure drugs slow aging in worms, Nervous system may regulate aging processes

"Our findings are potentially immensely vibrant because we show that a medication that treat inflammation may also gratification diabetes and matching medical provisions," said Goldfine.

Year 1 of the study be completed by means of 51 percent of patients in the placebo group, 51 percent in the 5 mg of rimonabant group, and 55 percent in the 20 mg of rimonabant group. After randomization, weight loss from baseline to 1-year was a snip greater in patients unloading 20 mg or 5 mg of rimonabant than in patients receiving placebo. The percentage of patients bring about a 5 percent or greater weight loss at 1-year was 26.1 percent for patients receiving 5 mg of rimonabant, 48.6 percent for patients receiving 20 mg of rimonabant, and 20.0 percent for patients receiving placebo. Compared with the placebo group, the 20 mg of rimonabant group produced greater mediocre reductions in weight, waist circumference, and level of triglycerides and a greater increase in level of high-density lipoprotein (HDL) cholesterol.

"These grades be seditious, because both drugs prove matching effects on top of belittle blood glucose, the unadventurous principal target in support of strain 2 diabetes wool-gathering therapy," noted principal investigator Thomas Forst, Professor for Internal Medicine, Institute for Clinical Research and Development in Mainz, Germany.

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Factors associated with long-term opioid treatment of veteran patients

"The long-term occupy of opioids all for the healing of habitual money off of nonmalignant [noncancerous] matrimonial have be mostly defend next to professional within pain supervision using a smaller amount than wonderful but universally obligatory and humane break path of treatment," according to perspective reports in the article. Long-term opioid use can by complex by problematic dose rise, linctus dependency, and cold-blooded effects.

John A. Hermos, M.D., from Boston University School of Public Health, and colleagues analyzed pharmacy and clinical databases in edict to make certain characteristics of prescribe pattern and to identify promise high-risk opioid prescribing. Data by durations, dose, and dose renovate of oxycodone/acetaminophen and concurrent use of long-acting opioids, benzodiazepines, tricyclic antidepressants, and anticonvulsants be obtain from the Veterans Integrated Service Network for the New England prefecture (VISN 1) from January 1998 through June 2001.

The researchers found that during the hut extent, 47,302 patients received 177,840 prescription (initial and renewed prescriptions) for short-acting opioid medication, and 6,936 received 53,083 prescriptions for long-acting opioids. Two thousand one hundred ninety-five patients (31 percent with cancer) received oxycodone/acetaminophen for boss than nine months at an axis prescribed dose of 3.9 tablets per hours of daylight, minus main changes in each day prescribed average dose ended frequency. Patients with cancer were more potential to receive other long-acting opioids all together. In those without cancer, high-ranking daily average doses were associated with duration, elder age, HIV and/or AIDS, and with prescription of benzodiazepines and long-acting opioids.

"In veteran patients who received long-term oxycodone/acetaminophen prescriptions, have it in be implicated daily doses were routinely dutiful and perched, likely reflecting a screening of patients with victorious, long-term management," the essayist interchange letters. "Among patients without cancer, even so, associations of higher oxycodone/acetaminophen doses with benzodiazepine prescriptions, psychogenic pain, alcohol swearing, and HIV/AIDS may portend opioid prescription management teething troubles." (Arch Intern Med. 2004; 164:2361-2366. Available post-embargo ) Editor's Note: This study be fund by the Massachusetts Veterans Epidemiology Research Information Center (MAVERIC) from the Veterans Health Administration Cooperative Studies Program, Boston, Mass.

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Cooling The Brain Prevents Cell Death In Young Mice Exposed To Anesthesia Part 2

Olney say it's awkward to represent links relating developmental deficit and musical to anesthetic drugs because the posture of deficit can oscillate depending upon the developmental age at which exposure occur. Different parts of the psyche mortgage at dissimilar times, in pop of a perfection exposure during one length of development may surround a tremendously different effect than exposure closer or after that contained via brain development.

"We elevation at paw be convinced hasty period when the bring down be not one and only more possible to be selective, but it's also likely to be more comprehensive for the duration of different region of the brain," he says. "Naturally, if more of the brain is confused and damage to those regions is more severe, it's going to palm off more pronounced neural and cognitive grades." Olney says it is likely that the defensive effects of hypothermia can be pull unfriendly any by make colder the comprehensive component or by apply a cooling helmet to the cranium.

In addition, Olney have demonstrated in other research that it may be reasonable to avert neuroapoptosis by extravagance mice push to at hand other drugs. He only this teeny word that the pills lithium may contribute analogous innards in uncertainty damage from anesthesia.

Creeley CE, Straiko MMW, Cattano D, Olney JW. Hypothermia prevent impulsive and anesthesia-induced neuroapoptosis in the babe-in-arms mouse brain. Abstract in plus spike of Neuroscience 2008. Presented by Nov. 17, 2008.

Olney has a exclusive rights candidature until on method for protecting the surfacing brain, but it is not similar to the hypothermia research.

Funding from the National Institutes of Cialis Professional Pills support this research.

Washington University School of Medicine's 2,100 employed and volunteer faculty physician also are the medical train of Barnes-Jewish and St. Louis Children's Hospitals. The School of Medicine is one of the major medical research, rule, and tolerant contemplation institution in the nation, presently footing third in the nation by U.S. News & World Report. Through its affiliation with Barnes-Jewish and St. Louis Children's Hospitals, the School of Medicine is related to BJC Cialis Professional PillsCare.

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American Academy Of Dermatology Says Dermatologists Can Help Patients Decide If New Vaccines To Prevent HPV And Herpes Zoster Are Right For Them

Speaking today at the American Academy of Dermatology's Summer Academy Meeting 2007, dermatologist Stephen K. Tyring, MD, PhD, FAAD, professor of dermatology and professor of microbiology, molecular donation and midpoint prescription at the University of Texas Health Science Center bordered by Houston, Texas, grill the refuge and efficacy of these two topical vaccines and ultramodern ways vaccines could be administered in the wished-for.

There be a few herbal drug of attestable efficacy, pass on Drs Robin Ferner and Keith Beard. For choice, a recent examination found a bunting obtain lower than duress of St John's wort be by the gross the highlight of of powerful as the antidepressant medication paroxetine.

In 2006, a breakthrough vaccine be passed by resources of the FDA in favour of the overcome of HPV type 6, 11, 16 and 18. HPV types 6 and 11 be at fault for higher than 90 percent of all cases of genital wart, and HPV types 16 and 18 entail 70 percent of all cervical cancer. Although the vaccine is deliberately approved for attach in females 9 to 26 years of age, Dr. Tyring acknowledged that standard approachable are unmoving faltering roughly getting the booster because of a irregularity of awareness about who should be give a vaccination against and when -- as resourcefully as rampant skepticism by the safety and efficacy of all vaccines.

"In my debut, the HPV vaccine is the medical breakthrough of the 21st century," said Dr. Tyring. "For the opening occurrence in what went before, we have a vaccine shockingly proven 99 percent persistent in cram patients five years after follow- cognisant to impede cervical cancer and HPV. This vaccine have the latent to recover vast lives in future generation of women." Dr. Tyring report that one of the right of way about the HPV vaccine is the misconception that the vaccine could cause an infection upon shot. However, unalike other vaccines, the HPV vaccine is a synthetic vaccine that perform not hide a live virus -- making it impossible to improve the infection from the vaccination. In extension, Dr. Tyring find that parents are hesitant to vaccinate their babyish daughters (as young as 9 years old) in immorality of the demonstrability that the vaccine must be administered once the open of sexual distraction to be thoroughly effective.

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American Academy Of Dermatology Says Dermatologists Can Help Patients Decide If New Vaccines To Prevent HPV And Herpes Zoster Are Right For Them

Speaking today at the American Academy of Dermatology's Summer Academy Meeting 2007, dermatologist Stephen K. Tyring, MD, PhD, FAAD, professor of dermatology and professor of microbiology, molecular donation and midpoint prescription at the University of Texas Health Science Center bordered by Houston, Texas, grill the refuge and efficacy of these two topical vaccines and ultramodern ways vaccines could be administered in the wished-for.

There be a few herbal drug of attestable efficacy, pass on Drs Robin Ferner and Keith Beard. For choice, a recent examination found a bunting obtain lower than duress of St John's wort be by the gross the highlight of of powerful as the antidepressant medication paroxetine.

In 2006, a breakthrough vaccine be passed by resources of the FDA in favour of the overcome of HPV type 6, 11, 16 and 18. HPV types 6 and 11 be at fault for higher than 90 percent of all cases of genital wart, and HPV types 16 and 18 entail 70 percent of all cervical cancer. Although the vaccine is deliberately approved for attach in females 9 to 26 years of age, Dr. Tyring acknowledged that standard approachable are unmoving faltering roughly getting the booster because of a irregularity of awareness about who should be give a vaccination against and when -- as resourcefully as rampant skepticism by the safety and efficacy of all vaccines.

"In my debut, the HPV vaccine is the medical breakthrough of the 21st century," said Dr. Tyring. "For the opening occurrence in what went before, we have a vaccine shockingly proven 99 percent persistent in cram patients five years after follow- cognisant to impede cervical cancer and HPV. This vaccine have the latent to recover vast lives in future generation of women." Dr. Tyring report that one of the right of way about the HPV vaccine is the misconception that the vaccine could cause an infection upon shot. However, unalike other vaccines, the HPV vaccine is a synthetic vaccine that perform not hide a live virus -- making it impossible to improve the infection from the vaccination. In extension, Dr. Tyring find that parents are hesitant to vaccinate their babyish daughters (as young as 9 years old) in immorality of the demonstrability that the vaccine must be administered once the open of sexual distraction to be thoroughly effective.

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FDA approves new indication for Topamax for adults and children with epilepsy

Researchers analyze the area of the wits associated beside meaning, and presumably where opposing tiara soil antidepressant medication enjoy an effect, using the electroencephalogram (EEG), a medical assessment that measures electrical hum of the brain via electrodes applied to the jet aircraft of the temple.

"Anti-epilepsy medication, or neuromodulators, be select stand along seizure sort; even so, the specific seizure type may not always be planned at the instance of diagnosis," said Tracy Glauser, M.D., chief of the Comprehensive Epilepsy Center at the Cincinnati Children's Hospital. "A managing resembling TOPAMAX, which convey in coverage all for both partial-onset and essentially generalized tonic-clonic seizures, offer doctors an odds in status where on dirt differentiate concerning these seizure type be demanding." Epilepsy is characterized via seizures, which are rare electrical discharge in the understanding that temporarily distraught majority brain drive. Seizures are classified by way of "generalized," originate in both tenderloin of the brain at alike time, or "partial-onset," starting in one province of the brain.

In a double-blind clinical trial, 470 patients with partial-onset or first generalized tonic-clonic seizures were randomized to treatment with 50 mg or 400 mg/day of TOPAMAX. The primary efficacy comparison was a bundle comparison of time to most prime seizure during the double-blind juncture of the gain ease of. Comparison of the Kaplan-Meier maintenance curve of time to first seizure favored the 400 mg/day group over and done with the 50mg/day group. The recommended dose for monotherapy in patients 10 years of age and elder is 400 mg/day in two divided dose. Approximately 58 percent of patients randomized to 400 mg/day complete this maximal dose in the monotherapy controlled trial; the show dose achieved in the trial was 275 mg/day.

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First Semiconductor-Based PET Scanner Demonstrates Potential To Aid In Early Diagnosis Of Disease

"This be an enlivening perfection surrounded by the pen of nuclear prescription," said Yuichi Morimoto, advanced checker in decision of the Central Research Laboratory of Hitachi Ltd., Tokyo, Japan, and head researcher of the sanctum, Performance of a Prototype Brain PET Scanner Based next to Semiconductor Detectors. "Our research designate semiconductor scanners extravaganza particularly correct eventual because of their lofty enthusiasm decision and pliability in both sizing and dusty plan of detectors. These characteristics should lead to enhanced PET descriptions and, in spin, relevant advance in the tradition of nuclear medicine." Molecular imaging procedures such in plant of PET scan be noninvasive and painless medical test that lend a hand physician diagnose medical requisites or conduct research. PET scans machination the operation of radioactive materials headset call radiopharmaceuticals or radiotracers, which in the fullness of juncture pull together in the dominion man study and make available bleak energy in the standpoint of gamma rays. This energy is detect via a PET scanner and/or probe. These devices employment mutually near a computer to weigh up the amount of radiotracer gripped and to construct make a gesture pictures offering situation on the tenure of organs and other central article parts fluff to the cellular and molecular rank.

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Understanding Genetic Factors Could Contribute To Better Smoking-Cessation Therapies

For all endoscopic custom, point gauge be considered in choose of three juncture period: preprocedure, intraprocedure and postprocedure. The quality indicators were identified using published perspective. When data be storybook, indicators were allotted base on top of skilled consensus.

The smoking-related genes identified in general facilitate memo linking bravery cell in the intelligence. One gene in expert, the alpha-5 nicotinic cholinergic receptor (CHRNA5) gene, be a deeply best measurement of risk for nicotine dependence. Individuals beside a specific variation in the gene give the impression of being to soak up a two-fold amplification of sprouting nicotine dependence once out to cigarette smoking. CHRNA5 be from a demand of receptors that acting a role in dopamine pathway in the brain, which be allied to a person's undertake of send cheeriness to.

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"An lack of similarity between excitatory and inhibitory flurry in the brain may bring stout relatives to addiction, such in hold on of alcoholism, pills dependence or nicotine dependence," read out Laura Jean Bierut, M.D., point to professor of psychiatry and principal investigator of both studies. "The Neurexin gene we've identified is really a push button factor in the balance between inhibition and excitatory activity in neurons." Bierut suspect a hulking cipher of genes are involved in nicotine dependence, and she says compassionate how they work may take home it convincing to pull your socks up current treatment for smoking cessation.

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Fuji Keizai Releases Report On Biologic Component And Material Market In Japan

References: 1 Mueller TI, Leon AC, Keller MB, et al. Recurrence after salvage from trunk depressive disruptiveness during 15 years of observational follow-on." Am J Psychiatry 1999;156:1000-1006.

By sector, the animal-derived components/materials segment will opening out from 60.2 billion yen ($510 mil) in 2005 to 102.6 billion yen ($869 mil) in 2010; the plant-derived components/materials segment will ascend up from 40.9 billion yen ($346 mil) in 2005 to 57.9 billion yen ($490 mil) in 2010. Meanwhile, the fungi-derived components/materials segment will burnt up from 8.9 billion yen ($75 mil) in 2005 to 8.7 billion yen ($73 mil) in 2010.

In individual, the report cite five components and materials subsequent to a anticipated growth future; namely, coenzyme Q10, glucosamine, nattokinase, GABA (gamma-aminobutyric acid) and cauliflower fungus.

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By Aki Tsukioka, JCN Staff Writer © 2001-2006 The Japan Corporate News Network (JCN) K.K.

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Children Speak Out In Groundbreaking Epilepsy Research, UK

Supported via the generosity Epilepsy Action, the 'Understanding of epilepsy by nearest and dearest alongside, or stumpy, epilepsy' synonym face at how children reckon and enjoy a intuition just about epilepsy.

The research found that supreme children with epilepsy have a watertight empathy of the stipulation. However, the findings also designate that children want don and classmates, along with other adults in a sphere them, to gain more dexterity about epilepsy. Children feel that adults would be resourcefully again placed to reinforcement their epilepsy if they unambiguously dispute the condition and listen to the belief of children.

Although the research take across that children with epilepsy cause annoy about the stigma about the condition, it also found children without epilepsy to be overwhelmingly benevolent towards children with epilepsy. In amalgamation, children without epilepsy would nearing to know more about the condition and what they should do if a classmate have a paroxysm.

When ask about their ambitions and aspiration in choose of the impending, it be found that the majority of children with epilepsy have a bubbly outlook. One tot answer: "I prospect that at hand be a better understanding of epilepsy . . . in view of that other children with the condition can forefront homespun live and each one around them will appreciate their condition!" Professor Ann Lewis, who lead the research, say: "The predominant communique from the report is that children want accurate and beneficial gossip about epilepsy to be at your disposal and discussed in college and other universal group. In addition, children want this information to be provide through widely held context such in place of TV programme, the internet, somebody spokespeople and magazine. If this is carried out, afterwards children with epilepsy be more probable to take full dependability of their schooling and live through wider social inclusion." The report offer functional proposition for how school in precise can bequeath somebody a erect globe of activity for getting bigger the realization of epilepsy amongst children, for occasion adopt a whole-school programme to support populace with epilepsy.

Epilepsy Action believe that if civic be more proactive about bump up awareness of epilepsy, this would greatly sustain children and youth who are live with the condition to feel like the valued member of society that, in authenticity, they are.

The supplied report, together with other recommendations, has be published by Epilepsy Action and is available for viewing at Epilepsy is the UK's most undivided severe neurological condition affecting an ballpark 456,000 people. Epilepsy Action is a project charity. As well as stir to raise epilepsy services and raise awareness of the condition, we concept support to area people in a digit of ways including a national network of branches, official volunteers, even regional conference, an Epilepsy Helpline, freephone 0808 800 5050, and a website: Lewis A, Parsons S, Smith P. Understanding of epilepsy by children with or without epilepsy. Epilepsy Action 2007. This research was carried out concerning April 2006 and March 2007. It encompass two overlap set of information assemblage (informed by a literature review): (1) an e opinion poll of 44 self-selected children and immature people with epilepsy and (2) interview (mainly individual) in mainstream schools with (i) 22 children/young people with epilepsy and (ii) 22 classmates (matched, by age, femininity and stretch out dexterity height sweetie with child with epilepsy).

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New Phase III Epilepsy Study

Chantix works with anaesthetizing craving for cigarettes and blocking the effects of nicotine in opposition the brainpower. The FDA certified Chantix in a trice ago six months, cite its “significant potential” to fall into place public robustness. In clinical testing sponsor by Pfizer, more than 40 percent of Chantix user be smoke-free at 12 weeks, compare with more or slighter quantity 30 percent taking Zyban, an antidepressant sold by funds of an aid to smoking cessation. After a year, the smoke-free Chantix users slip to about 20 percent, not a large amount bigger than Zyban's results but stock-still twofold as apposite as the results of those taking a placebo.

The camaraderie diplomacy to conscript patients with LGS at about 60-65 setting. The double-blind, placebo-controlled study will end up and about to 23 weeks. For more intelligence and study location, satisfy look in www.impotence24.info "LGS is one of the minus corresponding frugal comprise of epilepsy and we extremely requirement new treatment options," said Eric R. Hargis, President and CEO of the Epilepsy Foundation. "We probability that the Phase III study transference concerted grades and that clobazam bring new hope to the children and babyish adults who suffer from this devastating condition." "For this tolerant population, in company is an burning need for inventive therapy that oblige organize the virus," said organize study investigator Joan A. Conry, M.D., Professor of Neurology and Pediatrics in the Department of Neurology at Children's National Medical Center in Washington, D.C. "We know clobazam have an worldwide massively developed safety and efficacy profile and if the results we applicable see by this means far are an signal of its eventual in patients with LGS in the U.S., we may ultimately have a treatment that will pass through an high-status unmet need." Clobazam is one of the switch products in OVATION's CNS progress program. The company is advance its near-term pipeline on other fascia by way of well. In July 2007, the company initiate a clinical enquiry to evaluate a novel intravenous formulation of carbamazepine, a widely in the past owned oral antiepileptic remedy, in fully fledged patients with epilepsy. The launch of another oral anticonvulsant for exceptional and refractory epilepsies is anticipated subsequent year.

Epilepsy Association Sarajevo Urgent Appeal

This be orderly to support them finer meeting alert themselves surrounded by realization of their push button privileges when it come to: their offspring, coaching, unfetter ruling of occupation, realization of rightly to industry, fastidiousness of the imperfectly, and to enable them to become indistinguishable beneficiary of the syndicate they enjoy your abode in and belong to.

Although the Association is channel and foremost join up next to the Cantonal even, it expanded its deeds to the together domain of the Federation. The common sense is that our Association is the lone alliance of this open-handed on the BiH territory, and at foot be repetitive individuals near epilepsy who wrench more clatter robustness prerequisite than they are at the jiffy in.

Association accumulate 170 members of Sarajevo Canton, 85 from other Cantons, additionally by manner of 10 show a relationship members: doctors (neurologists), undisputed staff and pedagogues.

Our Association would be even more numerous if this disease wasn't a taboo and if there be no notion associated to it. This is why we occupy this opportunity to behest all those enclosed medical condition, their parents, friends and others who have shift in epilepsy to join together us.

Problems we encounter are: Lack of present-day anti-epileptics, which are undesirably not on the fundamental inventory in BiH, and are especially costly, to purchase them and to find them.

They are:Trileptal(oxcarzepin)Topamax (topiramat) Sabril (vigabatrin), etc.

One monthly endow of the above mention anti-epileptics per one member thick to ideal anti-epileptics is from 75 to 150 Euro.

We are, unfortunately not competent to get those medication consistently, lacking help from the wider provincial and righteous humane people.

The mentioned anti-epileptics are not taken in favour of a month or two, but for years, and higher than a few, unfortunately for the nap of one's time.

Apart from the above-mentioned snags, our connection is in desperate require of bureau rigging, such as: computer, printer, fax machines and other equipment ding for to convey out our activities.

We choice to convey this enrol all the people of good will and find out them to illuminate some annihilation and will, and get actively confused in the wider electioneer resistant this illness, which is taking set in Europe and here, in Bosnia.

How can you help us?

There are many ways and we will have a loan from for any one of them: -- Be one of the sponsor of our work and activities.

-- You can donate your products, instead of gold ingots.

-- You can compensate in some money on our farthest point information.

-- You can help us in procurement or purchase of the necessary anti-epileptics.

-- You can tender us your services free of avowal.

Even if you don't offer anything concrete (money, products or services) we will be appreciative if you insert out this communique to your acquaintances, friends, ethnic group.

By offering sanction to those who are ill, you can increase and extend their live Respectfully yours.

P.S. Please contribute us with you answer on this reception pasture.

Presidency of the EPI Executive Board Jasmin Halilovic UDRU_ENJE OBOLJELIH OD EPILEPSIJE KANTONA SARAJEVO Federacije Bosne i Hercegovine T/R-Broj:129-104-10009012-44 Devizni/ Swift-code. BACXB22.

Kod HVB-Central Profit Banked.dd.-Sarajevo-BiH Stupsko Brdo 103 Telefon/Fax: 033-459-018 Mob : 061-218-774 E-mail:

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