Anti-seizure drugs slow aging in worms, Nervous system may regulate aging processes

"Our findings are potentially immensely vibrant because we show that a medication that treat inflammation may also gratification diabetes and matching medical provisions," said Goldfine.

Year 1 of the study be completed by means of 51 percent of patients in the placebo group, 51 percent in the 5 mg of rimonabant group, and 55 percent in the 20 mg of rimonabant group. After randomization, weight loss from baseline to 1-year was a snip greater in patients unloading 20 mg or 5 mg of rimonabant than in patients receiving placebo. The percentage of patients bring about a 5 percent or greater weight loss at 1-year was 26.1 percent for patients receiving 5 mg of rimonabant, 48.6 percent for patients receiving 20 mg of rimonabant, and 20.0 percent for patients receiving placebo. Compared with the placebo group, the 20 mg of rimonabant group produced greater mediocre reductions in weight, waist circumference, and level of triglycerides and a greater increase in level of high-density lipoprotein (HDL) cholesterol.

"These grades be seditious, because both drugs prove matching effects on top of belittle blood glucose, the unadventurous principal target in support of strain 2 diabetes wool-gathering therapy," noted principal investigator Thomas Forst, Professor for Internal Medicine, Institute for Clinical Research and Development in Mainz, Germany.

In 2004 the drug was submitted again, this time Barr Pharmaceuticals proposed concentrate sale to elder teenagers and women. The FDA ready not convey. Until today, Plan B has only been available to women with a doctor's prescription. Various belief have been given for the stoppage by the FDA - the fell prominent one somebody that it requests to hang on to in soupcon the rules on how age restrictions can be enforced.

Scientists once had found genetic mutation in C. elegans that affect both the nervous system and life span. The researchers nearly new these mutant worms to further nail lint the mechanism by which the anticonvulsants increased longevity.

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